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- Phosphorylation Analysis Service
Measurement of “activity” as well as “quantity” by an environment that mimics a living state
This is a technology that approaches the reality of phosphorylation with a novel approach (Download our promotion document, below).
This technology has been well received not only in Japan but also in the U.S. and China, where we are expanding our services.
・Analysis technology
・Achievements
Analysis technology
Please see the document (PDF file) for details.
For inquiries and quotes, please contact us.
Achievements
- 1. X. Hu, L. Li, J. Nkwocha, M. Kmieciak, S. Shang, L. Cowart, Y. Yue, K. Horimoto, A. Hawkridge, A. Rijal, A. G. Mauro, F. N. Salloum, L. Hazlehurst, K. Sdrimas, Z. Moore, L. Zhou, G. D. Ginder, S. Grant: Src inhibition potentiates MCL-1 antagonist activity in acute myeloid leukemia. Sig Transduct Target Ther 10, 50 (2025). https://doi.org/10.1038/s41392-025-02125-x [Joint research with Virginia Commonwealth University]
- 2. R. Shimizu, Ryogo, K. Murai, K. Tanaka, Y. Sato, N. Takeda, S. Nakasyo, T. Shirasaki, K. Kawaguchi, T. Shimakami, K. Nio, Y. Nakaya, H. Kagiwada, K. Horimoto, M. Mizokami, S. Kaneko, K. Murata, T. Yamashita, M. Honda: Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes. Hepatology Communications 8(1):e0351, January 2024 [Joint research with Kanazawa University School of Medicine]
- 3. Horimoto, K., Suyama, Y., Sasaki, T., Fukui, K., Sun, M., Feng, L., Tang, Y., Zhang, Y., Chen, D., Han F. : Phosphorylated protein chip combined with artificial intelligence tools for precise drug screening. The Journal of Biomedical Research. 38(3): 195-205, 2024 [Joint research with Nanjing Medical University]
- 4. Feng, L., Chen, X., Sheng, G., Li, Y., Li, Y., Zhang, Y., Yao, K., Wu, Z., Zhang, R., Kiboku, T. Kawasaki, A., Horimoto, K., Tang, Y., Sun, M., Han, F., Chen, D. : Synthesis and Bioevaluation of 3-(Arylmethylene) indole Derivatives: Discovery of a Novel ALK Modulator with Anti-glioblastoma Activities. Journal of Medicinal Chemistry 66(21): 14609-14622, 2023 [Joint research with Nanjing Medical University]
- 5. Kagiwada, H., Motono, C., Horimoto, K., Fukui, K. : Phosprof: pathway analysis database of drug response based on phosphorylation activity measurements. Database. Vol. 2022: article ID baac072, 2022 [Joint research with AIST]
- 6. H. Kagiwada, T. Kiboku, H. Matsuo, M. Kitazawa, K. Fukui, K. Horimoto: Assessing the activation/inhibition of tyrosine kinase-related pathways with a newly developed platform, Proteomics, 21(16):e2000251, 2021 [Joint research with AIST]
- 7. T. Tomonari, Y. Sato, H. Tanaka, T. Tanaka, Y. Fujino, Y. Mitsui, A. Hirao, K. Okamoto, H. Miyamoto, N. Muguruma, H. Kagiwada, M. Kitazawa, K. Fukui, K. Horimoto, T. Takayama: Potential use of lenvatinib for patients with unresectable hepatocellular carcinoma including after treatment with sorafenib: Real-world evidence and in vitro assessment via protein phosphorylation array. Oncotarget, 11(26): 2531–2542､2020. [Joint research with Tokushima University School of Medicine]
- 8. Manabe, T., Yasuda, H., Terai, H., Kagiwada, H., Hamamoto, J., Ebisudani, T., Kobayashi, K., Masuzawa, K., Ikemura, S., Kawada, I., Hayashi, Y., Fukui, K., Horimoto, K., Fukunaga, K., Soejima, K.: IGF2 autocrine-mediated IGF1R activation is a clinically relevant mechanism of osimertinib resistance in lung cancer. MOL CANCER RES, 549-559, 18, 2020. [Joint research with Keio University School of Medicine]
Please see the document (PDF file) for details.
For inquiries and quotes, please contact us.